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Notch 2 polyclonal antibody

CAT: 0384-BS7044-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS7044-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Notch proteins (Notch1-4) are a family of transmembrane receptors that play important roles in development and the determination of cell fate. Mature Notch receptors are processed and assembled as heterodimeric proteins, with each dimer comprised of a large extracellular ligand-binding domain, a single-pass transmembrane domain, and a smaller cytoplasmic subunit (Notch intracellular domain, NICD) . Binding of Notch receptors to ligands of the Delta-Serrate-Lag2 (DSL) family triggers heterodimer dissociation, exposing the receptors to proteolytic cleavages; these result in release of the NICD, which translocates to the nucleus and activates transcription of downstream target genes. Notch2 is a member of the Notch family and mutation in Notch2 is associated with Alagille syndrome.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Product Name Alternative
Notch 2; Hn2; N2ECD; N2ICD; NOTCH2
Swiss Prot
Q04721
Reactivity
Human
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Notch 2.
Conjugation
Unconjugated
Related Pathways
Notch Signaling, Contribution of Soluble Factors to EMT
Applications
WB IHC
Dilution
WB: 1:500~1:1000 IP:1:100~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Molecular Weight
~ 110 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Notch 2 polyclonal antibody detects endogenous levels of Notch 2 protein.
Applications Notes
Western blot analysis of Notch 2 expression in HEK293T (A), HepG2 (B) whole cell lysates.
Host or Source
Rabbit

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