RIP polyclonal antibody

CAT: 0384-BS91172-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0384-BS91172-01Size:50 µL
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
In contrast to growth factors which promote cell proliferation, FAS ligand (FAS-L) and the tumor necrosis factors (TNFs) rapidly induce apoptosis. Cellular response to FAS-L and TNF is mediated by structurally related receptors containing a conserved "death domain" and belonging to the TNF receptor superfamily. TRADD, FADD and RIP are FAS/TNF-R1 interacting proteins that contain a death domain homologous region (DDH) . TRADD (TNF-R1-associated death domain) and FADD (FAS-associated death domain) associate with the death domains of both FAS and TNF-R1 via their DDH regions. Overexpression of TRADD leads to NFkB activation and apoptosis in the absence of TNF. Overexpression of FADD causes apoptosis, which can be blocked by the cow pox protein CrmA, suggesting that FADD lies upstream of ICE and possibly other serine proteases. The receptor interacting protein, RIP, associates with FAS exclusively via its DDH and this association is abrogated in lpr mutants. Unlike TRADD and FADD, RIP contains a putative amino terminal kinase domain.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
RIP-1, RIPK1, Cell death protein RIP, FLJ39204, OTTHUMP00000039163, Receptor (TNFRSF) interacting serine threonine kinase 1, receptor interacting protein 1, Receptor interacting protein, Receptor interacting protein kinase 1, Receptor interacting serine threonine protein kinase 1, Receptor TNFRSF interacting serine threonine kinase 1, Receptor-interacting protein 1, Receptor-interacting serine/threonine-protein kinase 1, Rinp, RIP 1, RIP, Rip-1, RIP1, RIPK 1, Ripk1, RIPK1, Serine threonine protein kinase RIP, Serine/threonine-protein kinase RIP
Swiss Prot
Q13546 (Human)
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein
Conjugation
Unconjugated
Related Pathways
Toll-like Receptor signaling
Applications
WB FC
Dilution
WB:1:1,000-1:5,000 FC:1:50-1:100
Purity
ProA affinity purified
Modification
Unmodified
Molecular Weight
~ 76-90 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
RIP polyclonal antibody detects endogenous levels of RIP protein.
Applications Notes
Western blot (WB) analysis of RIP pAb at 1:1000 dilution Lane1:C6 whole cell lysate (40ug) Lane2:3T3-L1 whole cell lysate (40ug) Lane3:The Brain tissue lysate of Mouse (40ug) Lane4:The Stomach tissue lysate of Rat (40ug) Lane5:DLD whole cell lysate (40ug) Lane6:SGC7901 whole cell lysate (40ug)
Host or Source
Rabbit

Related Products

CatalogName
MB11533RIP monoclonal antibody
MB11534RIP monoclonal antibody
BS49491-01RIP Recombinant Rabbit mAb
BS45972-01RIP Recombinant Rabbit mAb
BS45237RIP Recombinant Rabbit mAb
PPL00506-3aPPLK/GFP+Puro-RIP shRNA-1
BS65635RIP2 Polyclonal Antibody
BZ16794-01Polyclonal antibodyPN1 polyclonal antibody
BS6114-01PPP3CA polyclonal antibody
BS78576-01PISD polyclonal antibody

Alternative Products

CatalogName
AMR09397GPolyclonal PML polyclonal antibody
APR12450GPolyclonal JARID2 polyclonal antibody
AMM05547GPolyclonal ACTL6B polyclonal antibody
AMM06350GPolyclonal MeCP2 polyclonal antibody
APR17846GPolyclonal PIWIL2 polyclonal antibody
APR00438GPolyclonal MYH11 polyclonal antibody
APR00437GPolyclonal RARA polyclonal antibody
APR00439GPolyclonal EZH2 polyclonal antibody
APR00445GPolyclonal HDAC1 polyclonal antibody
APR00450GPolyclonal JMJD2c polyclonal antibody

Popular Products