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GRK 2 (D635) polyclonal antibody

CAT: 0384-BS1963-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS1963-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. This phenomenon, referred to as agonistmediated desensitization, involves phosphorylation of the receptor by two classes of enzymes. The first are the second messenger-regulated kinases such as c-AMP dependent protein kinase A and protein kinase C. The second are the G protein-coupled receptor kinases (GRKs) . At least seven members of the GRK family have been identified. These include rhodopsin kinase, GRK 1; two forms of β-adrenergic receptor kinase, GRK 2 (βARK, βARK1) and GRK 3 (βARK2) ; IT-11 (GRK 4) ; GRK 5, GRK 6 and GRK 7. Phosphorylation of receptors by GRKs appears to be strictly dependent on the receptor being in its agonist-activated state.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Beta-adrenergic receptor kinase 1; Beta-ARK-1; β-ARK-1; ARK-β1; G-protein coupled receptor kinase 2; ADRBK1; BARK; BARK1; GRK2; ARK β1; ARKβ1; β-ARK1
Swiss Prot
P25098
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 600-650 of Human GRK2.
Conjugation
Unconjugated
Related Pathways
G Protein-coupled Receptors Signaling to MAPK Erk
Applications
WB IHC IP
Dilution
WB: 1:500~1:1000 IHC: 1:50~1:200 IP: 1:10~1:100
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Molecular Weight
~ 80 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
GRK 2 (D635) polyclonal antibody detects endogenous levels of GRK 2 protein.
Applications Notes
Western blot (WB) analysis of GRK2 (D635) pAb at 1:500 dilution Lane1:MEF whole cell lysate (40ug) Lane2:C6 whole cell lysate (40ug) Lane3:MCF-7 whole cell lysate (40ug) Lane4:PC3 whole cell lysate (40ug) Lane5:K562 whole cell lysate (40ug)
Host or Source
Rabbit

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