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Tuberin (L1456) polyclonal antibody

CAT: 0384-BS1605-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS1605-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Tuberin is a product of the TSC2 tumor suppressor gene and an important regulator of cell proliferation and tumor development. Mutations in either TSC2 or the related TSC1 (hamartin) gene cause tuberous sclerosis complex (TSC), an autosomal dominant disorder characterized by development of multiple, widespread non-malignant tumors. Tuberin is directly phosphorylated at Thr1462 by Akt/PKB. Phosphorylation at Thr1462 and Tyr1571 regulates tuberin-hamartin complexes and tuberin activity. In addition, tuberin inhibits the mammalian target of rapamycin (mTOR), which promotes inhibition of p70 S6 kinase, activation of eukaryotic initiation factor 4E binding protein 1 (4E-BP1, an inhibitor of translation initiation), and eventual inhibition of translation.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Product Name Alternative
Tuberin; Tuberous sclerosis 2 protein
Swiss Prot
P49815
Reactivity
Human, Rat, Mouse
Immunogen
Synthetic peptide, corresponding to Human Tuberin.
Conjugation
Unconjugated
Related Pathways
Insulin &Glucose Signaling
Applications
WB IF
Dilution
WB: 1:5000~1:20000 IF: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95%
Modification
Unmodified
Molecular Weight
~ 200 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Tuberin (L1456) polyclonal antibody detects endogenous levels of Tuberin protein.
Applications Notes
Western blot (WB) analysis of Tuberin (L1456) polyclonal antibody at 1:2000 dilution Lane1:THP-1 whole cell lysate (40ug) Lane2:K562 whole cell lysate (40ug) Lane3:PC3 whole cell lysate (40ug)
Host or Source
Rabbit

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