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CREB (phospho-S133) polyclonal antibody

CAT: 0384-BS4053-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS4053-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Cyclic AMP Response Element Binding protein (CREB) is a basic / leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors. Activation of CREB is dependent upon the phosphorylation of serine 133. Phosphorylation occurs via p44 / 42 MAP kinase and p90RSK and also via p38 MAP kinase and MSK 1. Although CREB will bind DNA independent of its phosphorylation state, only the phosphorylated form is competent as a transcription factor. CREB binding protein (CBP), a transcriptional coactivator that directly interacts with CREB, binds to CREB in the region of serine 133.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Cyclic AMP-responsive element-binding protein 1; CREB-1; cAMP-responsive element-binding protein 1; CREB1
Swiss Prot
P16220
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic phosphopeptide derived from human CREB around the phosphorylation site of Serine 133.
Conjugation
Unconjugated
Related Pathways
ErbB HER Signaling, MAPK Erk in Growth and Differentiation Pathway, Inhibition of Apoptosis, Dopamine Signaling in Parkinson\'s Disease Plathway, Signaling Pathways Activating p38 MAP Kinase, T cell receptor signaling
Applications
WB IHC IP
Dilution
WB: 1:500~1:1000 IHC: 1:100~1:200 IP: 1:10~1:100
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Phosphorylated
Molecular Weight
~ 43 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
P-CREB (S133) polyclonal antibody detects endogenous levels of CREB-1 protein only when phosphorylated at Ser133.
Applications Notes
Western blot analysis of CREB (Phospho-S133) expression in C6 (A), NIH3T3 (B), HEK293T (C), H1792 (D) whole cell lysates.
Host or Source
Rabbit

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