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LYVE1 polyclonal antibody

CAT: 0384-AP0017-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-AP0017-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Recently a number of interesting molecules have been identified that may be exploited as markers for lymphatic endothelium, including the hyaluronan receptor LYVE1, PALE, VEGFR3, podoplanin. LYVE1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE1 molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Cell surface retention sequence-binding protein 1; CRSBP 1; CRSBP-1; CRSBP1; extracellular link domain containing 1; extracellular link domain-containing 1; Extracellular link domain-containing protein 1; HAR; hyaluronic acid receptor; Lymphatic endothelium specific hyaluronan receptor; lymphatic vessel endothelial hyaluronan receptor 1; Lymphatic vessel endothelial hyaluronic acid receptor 1; LYVE 1; LYVE-1; LYVE1; LYVE1; XLKD1
Swiss Prot
Q9Y5Y7
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 60-110 of Human LYVE-1.
Conjugation
Unconjugated
Applications
WB IF
Dilution
WB: 1:500~1:1000 IF: 1:100~1:500
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Molecular Weight
~ 36 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
LYVE-1 polyclonal antibody detects endogenous levels of LYVE-1 protein.
Applications Notes
Western blot (WB) analysis of LYVE1 pAb at 1:500 dilution Lane1:CT26 whole cell lysate (40ug) Lane2:C6 whole cell lysate (40ug) Lane3:HCT116 whole cell lysate (40ug) Lane4:MCF-7 whole cell lysate (40ug) Lane5:SGC7901 whole cell lysate (40ug)
Host or Source
Rabbit

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