Alpha Synuclein Antibody (Aggregate-Specific), Clone 2F11

CAT: 0400-SMC-617SSize: 12 µgDry Ice: NoHazardous: No
CAT#:0400-SMC-617SSize:12 µg
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Background
Alpha-synuclein (SNCA) is a presynaptic neuronal protein abundantly expressed in the brain, particularly within the olfactory bulb, hippocampus, striatum, and thalamus (1,2) . Localized to both synaptic terminals and mitochondria, alpha-synuclein plays a critical role in synaptic vesicle regulation and cytoskeletal dynamics through its interaction with tubulin (3), suggesting a potential function as a microtubule-associated protein. It is also essential for cognitive development, with SNCA inactivation linked to deficits in spatial learning and working memory (4) . Pathologically, alpha-synuclein aggregates are a defining feature of several neurodegenerative diseases. These fibrillar inclusions constitute the major non-Aβ component of amyloid plaques in Alzheimer’s disease and are the principal constituents of Lewy bodies in Parkinson’s disease (PD) . In PD, progressive accumulation of alpha-synuclein and ubiquitin-positive inclusions in dopaminergic neurons is closely associated with motor and cognitive decline (5,6) . Alpha-synuclein aggregation is not merely a byproduct of disease but a driver of neurotoxicity, mitochondrial dysfunction, and synaptic failure. Its central role in disease pathogenesis has made it a high-priority target for biomarker development and therapeutic intervention. Covered by US patent family US11,098,108B2 (7) .
Description
Mouse Anti-Mouse Alpha Synuclein Aggregate Antibody Monoclonal IgG1
CAS Number
9007-83-4
Specifications
Binds a 3-dimensional fibrillar epitope including AA101-120, AA61-80
Product Name Alternative
Alpha Synuclein, α-Synuclein, SNCA, Snca, SYN, alphaSYN, NACP, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, Parkinson disease familial 1, PARK1, PARK 1, PARK4, PARK 4, Parkinson disease (autosomal dominant, Lewy body) 4, Lewy body 4, Synuclein-alpha, PD1
Synonyms
Alpha Synuclein Antibody (Aggregate-Specific), Clone 2F11
UNSPSC
12352203
UN Code
Non-hazardous
Hazard Statement
Non-hazardous
Gene ID
20617
Swiss Prot
O55042
Accession Number
NP_001035916.1
Cellular Locus
Cell Junction, Cytoplasm, Cytosol, Membrane, Nucleus, Synapse
Host
Mouse
Species Reactivity
Human, Mouse
Immunogen
Mouse alpha synuclein fibrils
Target
Alpha Synuclein Aggregate Antibody
Clonality
Monoclonal
Isotype
IgG1
Clone
2F11
Conjugation
Unconjugated
Type
Monoclonal
Applications
WB | DB | IP | IHC | ICC-IF | ImmunoGold labelling
Validated Applications
WB, DB, IP, IHC, ICC-IF, ImmunoGold labelling
Field of Research
Alzheimer's Disease | Neurodegeneration | Neuroscience | Synuclein | Tangles & Tau | Multiple System Atrophy
Purification
Protein G Purified
Limit Of Detection
A 1:1000 dilution of SMC-617 was sufficient for detection of Alpha Synuclein aggregates in 15 µg of human brain cell lysate by ECL immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
Concentration
1mg/ml
Dilution
WB (1:1000) . Application specific; optimal dilutions for assays should be determined by the user.
Weight
0.012
Buffer
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. “Genetics Home Reference: SNCA”. US National Library of Medicine. (2013). 2. Zhang L., et al. (2008) Brain Res. 1244: 40-52. 3. Alim M.A., et al. (2002) J Biol Chem. 277(3): 2112-2117. 4. Kokhan V.S., Afanasyeva M.A., Van'kin G. (2012) Behav. Brain. Res. 231(1): 226-230. 5. Spillantini M.G., et al. (1997) Nature. 388(6645): 839-840. 6. Mezey E., et al. (1998) Nat Med. 4(7): 755-757. 7. Louwrier, A. US Patent family US11,098,108 B2
Shipping Conditions
Blue Ice or 4ºC
Storage Conditions
-20ºC
Specificity
This antibody binds a 3-dimensional fibrillar epitope of alpha synuclein (including AA101-120, AA61-80), present in MSA (Multiple System Atrophy) aggregates in human brain samples. It does not appear to detect PD (Parkinson's disease) or PDLB (Parkinson's disease with Lewy Bodies) aggregate structures in human brain samples. It can, however, bind recombinant human PFFs and mouse PFFs.
Background Reference 01
1. “Genetics Home Reference: SNCA”. US National Library of Medicine. (2013) . 2. Zhang L., et al. (2008) Brain Res. 1244: 40-52. 3. Alim M.A., et al. (2002) J Biol Chem. 277 (3) : 2112-2117. 4. Kokhan V.S., Afanasyeva M.A., Van'kin G. (2012) Behav. Brain. Res. 231 (1) : 226-230. 5. Spillantini M.G., et al. (1997) Nature. 388 (6645) : 839-840. 6. Mezey E., et al. (1998) Nat Med. 4 (7) : 755-757. 7. Louwrier, A. US Patent family US11,098,108 B2
Species
Human | Mouse
Location
Cell Junction, Cytoplasm, Cytosol, Membrane, Nucleus, Synapse
Isotype
IgG1
Immunogen Species
Mouse

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