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Kobophenol A

CAT: 0804-HY-126419-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-126419-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Kobophenol A, an oligomeric stilbene, blocks the interaction between the ACE2 receptor and S1-RBD with an IC50 of 1.81 μM and inhibits SARS-CoV-2 viral infection in cells with an EC50 of 71.6 μM. Kobophenol A inhibits the activity of partially purified rat brain protein kinase C (PKC) with an IC50 of 52 µM[1][2].
CAS Number
124027-58-3
UNSPSC
12352005
Target
PKC; SARS-CoV
Type
Natural Products
Related Pathways
Anti-infection; Epigenetics; TGF-beta/Smad
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/kobophenol-a.html
Purity
99.90
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1=CC([C@H]([C@@H](C(C=C2)=CC=C2O)OC3=C4)C3=C([C@@H]5[C@H](C6=CC(O)=CC(O)=C6)[C@@H](C(C=C7)=CC=C7O)O[C@@H]5C(C=C8)=CC=C8O)C=C4O)=C9[C@@H](C%10=CC(O)=CC(O)=C%10)[C@H](C(C=C%11)=CC=C%11O)OC9=C1
Molecular Formula
C56H44O13
Molecular Weight
924.94
References & Citations
[1]Gangadevi S, et al. Kobophenol A Inhibits Binding of Host ACE2 Receptor with Spike RBD Domain of SARS-CoV-2, a Lead Compound for Blocking COVID-19. J Phys Chem Lett. 2021;12 (7) :1793-1802.|[2]Xu G, Zhang LP, Chen LF, Hu CQ. Yao Xue Xue Bao. 1994;29 (11) :818-822.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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