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STAT5b [SD08-08] Antibody

CAT: 1071-OM637587-01Size: 100 µLDry Ice: NoHazardous: No
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CAT#:1071-OM637587-01Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Signal transducer and activator of transcription 5A (Stat5a) and Stat5b, which share 96% homology, undergo receptor tyrosine kinase or G protein-coupled receptor-dependent phosphorylation in response to cytokines or growth factors, and then form homo- or heterodimers that translocate to the nucleus, where they initiate transcription. Activation of Stat5a via IL-2, IL-3, IL-7/ GM-CSF, erythropoietin, thrombopoietin and growth hormones influences proliferation, differentiation and apoptosis in lymphohematopoietic cells. Phos-phorylation of Stat5a at Ser127/Ser128 and Ser779 are contigent on ErbB-4-mediated activation of Stat5a. Activation of Stat5b via IL-2, IL-4, CSF-1 and growth hormones influences TCR signaling, apoptosis, adult mammary gland development and sexual dimorphism of liver gene expression. Stat5b is the major liver-expressed Stat5 form that has been shown to fuse with the retin-oic acid receptor a gene in acute promyelocytic leukemias (APLL) . Stat5a/b null mice have severely impaired lymphoid development and differentiation.
CAS Number
9007-83-4
Immunogen
Recombinant protein
Antibody Type
Primary Antibodies
Product Name Synonym
Signal transducer and activator of transcription 5B antibody STA5B_HUMAN antibody STAT5 antibody Stat5b antibody Transcription factor STAT5B antibody

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