14-3-3 Theta [SD084-02] Antibody

• Description:

  14-3-3 proteins regulate many cellular processes relevant to cancer biology, notably apoptosis, mitogenic signaling and cell-cycle checkpoints. Seven isoforms comprise this family of signaling intermediates, denoted 14-3-3 β, γ, ε, ζ, η, θ and σ. 14-3-3 proteins form dimers that present two binding sites for ligand proteins, thereby bringing together two proteins that may not otherwise associate. These ligands largely share a 14-3-3 consensus binding motif and exhibit serine/threonine phosphorylation. 14-3-3 proteins function in broad regulation of these ligand proteins, by cytoplasmic sequestration, occupation of interaction domains and import/export sequences, prevention of degradation, activation/repression of enzymatic activity and facilitation of protein modification, and thus loss of expression contributes to a vast array of pathogenic cellular activities.

• Immunogen:

  Recombinant protein

• Antibody Type:

  Primary Antibodies

• Product Name Synonym:

  14-3-3 antibody 14-3-3 protein T-cell antibody 14-3-3 protein tau antibody 14-3-3 protein theta antibody 1C5 antibody HS1 antibody theta polypeptide antibody tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein antibody tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta isoform antibody tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide antibody

• CAS Number:

  9007-83-4