Desipramine

• Description :

  Desipramine is a tricyclic psychotic compound, possessing antidepressant activity. Desipramine inhibits the norepinephrine reuptake receptor in the central nervous system and reduces the sleep-related loss of genioglossus activity, can be used to research the improvement of pharyngeal collapsibility[1][2].

• UNSPSC :

  12352005

• Hazard Statement :

  H315-H319-H320

• Target :

  Adrenergic Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease; Cancer

• Assay Protocol :

  https://www.medchemexpress.com/desipramine.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CNCCCN1C2=CC=CC=C2CCC3=CC=CC=C31

• Molecular Formula :

  C18H22N2

• Molecular Weight :

  266.38

• Precautions :

  P264-P280-P302+P352-P305+P351+P338-P362

• References & Citations :

  [1]Garcia AS, et al. Autoreceptor-mediated inhibition of norepinephrine release in rat medial prefrontal cortex is maintained after chronic desipramine treatment. J Neurochem. 2004 Nov;91 (3) :683-93.|[2]Taranto-Montemurro L, et al. Desipramine improves upper airway collapsibility and reduces OSA severity in patients with minimal muscle compensation. Eur Respir J. 2016 Nov;48 (5) :1340-1350.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Citation 01 :

  Research Square Print. 2023 Feb 23.|Biochim Biophys Acta Mol Basis Dis. 2023 Mar 28;1869 (5) :166700.|Br J Pharmacol. 2024 Dec;181 (23) :4874-4889.|Cell. 2025 Oct 24:S0092-8674 (25) 01131-6.|Glia. 2022 Nov;70 (11) :2093-2107.|Inflammation. 2021 Aug;44 (4) :1592-1606.|J Parkinson Dis. 2020;10 (2) :523-542.|Neural Regen Res. 2021 Aug;16 (8) :1660-1670.|Neuroscience. 2024 Mar 26:542:11-20.|Neurotoxicology. 2022 Dec:93:173-185.|Parkinsons Dis. 2022 Nov 14:2022:1428817.|Pharmaceutics. 2022 Jul 22;14 (8) :1523.|Sci Total Environ. 2024 May 1:923:171405.

• CAS Number :

  [50-47-5]