Desipramine

• UNSPSC Description:

  Desipramine is a tricyclic psychotic compound, possessing antidepressant activity. Desipramine inhibits the norepinephrine reuptake receptor in the central nervous system and reduces the sleep-related loss of genioglossus activity, can be used to research the improvement of pharyngeal collapsibility[1][2].

• Target Antigen:

  Adrenergic Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/desipramine.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CNCCCN1C2=CC=CC=C2CCC3=CC=CC=C31

• Molecular Weight:

  266.38

• References & Citations:

  [1]Garcia AS, et al. Autoreceptor-mediated inhibition of norepinephrine release in rat medial prefrontal cortex is maintained after chronic desipramine treatment. J Neurochem. 2004 Nov;91(3):683-93.|[2]Taranto-Montemurro L, et al. Desipramine improves upper airway collapsibility and reduces OSA severity in patients with minimal muscle compensation. Eur Respir J. 2016 Nov;48(5):1340-1350.Research Square Print. 2023 Feb 23.|Biochim Biophys Acta Mol Basis Dis. 2023 Mar 28;1869(5):166700.|Br J Pharmacol. 2024 Sep 5.|Glia. 2022 Jul 1.|Inflammation. 2021 Mar 4.|J Parkinson Dis. 2020;10(2):523-542.|Neural Regen Res. 2021;16:1660-70.|Neuroscience. 2024 Feb 8:542:11-20.|Neurotoxicology. 2022 Oct 6;S0161-813X(22)00156-5.|Parkinsons Dis-us. 2022.|Pharmaceutics. 2022, 14(8), 1523.|Sci Total Environ. 2024 Mar 1:923:171405.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  Launched

• CAS Number:

  50-47-5