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Trimipramine

CAT: 0804-HY-B1213ASize: 1 EachDry Ice: NoHazardous: No
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Description
Trimipramine is a 5-HT receptor antagonist, with pKi binding values of 6.39, 8.10, 4.66 for 5-HT1C, 5-HT2 and 5-HT1A, respectively. Trimipramine is also a potent and selective inhibitor targeting human noradrenaline (hNAT), serotonin (hSERT) and organic cation transporters (hOCT1, hOCT2) with IC50 values of 4.99 μM, 2.11 μM, 3.72 μM, 8.00 μM, respectively. Trimipramine has vascular activity and anxiolytic efficacy[1][2][3].
CAS Number
739-71-9
UNSPSC
12352005
Hazard Statement
H225-H301+H311+H331-H370
Target
5-HT Receptor; Bacterial
Type
Reference compound
Related Pathways
Anti-infection; GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/trimipramine.html
Solubility
10 mM in DMSO
Smiles
CC(CN1C2=CC=CC=C2CCC3=C1C=CC=C3)CN(C)C
Molecular Formula
C20H26N2
Molecular Weight
294.43
Precautions
P210-P233-P240-P241-P242-P243-P260-P261-P264-P270-P271-P280-P302+P352-P303+P361+P353-P304+P340-P308+P311-P330-P361+P364-P370+P378-P403+P233-P403+P235-P405-P501
References & Citations
[1]Jenck F, et al. Evidence for a role of 5-HT1C receptors in the antiserotonergic properties of some antidepressant drugs. Eur J Pharmacol. 1993 Feb 9. 231 (2) :223-9.|[2]Juorio AV, et al. The effects of chronic trimipramine treatment on biogenic amine metabolism and on dopamine D2, 5-HT2 and tryptamine binding sites in rat brain. Gen Pharmacol. 1990. 21 (5) :759-62. |[3]Haenisch B, et al. Inhibitory potencies of trimipramine and its main metabolites at human monoamine and organic cation transporters. Psychopharmacology (Berl) . 2011 Sep. 217 (2) :289-95.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
5-HT1 Receptor; mLAG-3; α-1 microglobulin

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