Trimipramine

• Description :

  Trimipramine is a 5-HT receptor antagonist, with pKi binding values of 6.39, 8.10, 4.66 for 5-HT1C, 5-HT2 and 5-HT1A, respectively. Trimipramine is also a potent and selective inhibitor targeting human noradrenaline (hNAT), serotonin (hSERT) and organic cation transporters (hOCT1, hOCT2) with IC50 values of 4.99 μM, 2.11 μM, 3.72 μM, 8.00 μM, respectively. Trimipramine has vascular activity and anxiolytic efficacy[1][2][3].

• UNSPSC :

  12352005

• Hazard Statement :

  H225-H301+H311+H331-H370

• Target :

  5-HT Receptor; Bacterial

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/trimipramine.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC(CN1C2=CC=CC=C2CCC3=C1C=CC=C3)CN(C)C

• Molecular Formula :

  C20H26N2

• Molecular Weight :

  294.43

• Precautions :

  P210-P233-P240-P241-P242-P243-P260-P261-P264-P270-P271-P280-P302+P352-P303+P361+P353-P304+P340-P308+P311-P330-P361+P364-P370+P378-P403+P233-P403+P235-P405-P501

• References & Citations :

  [1]Jenck F, et al. Evidence for a role of 5-HT1C receptors in the antiserotonergic properties of some antidepressant drugs. Eur J Pharmacol. 1993 Feb 9. 231 (2) :223-9.|[2]Juorio AV, et al. The effects of chronic trimipramine treatment on biogenic amine metabolism and on dopamine D2, 5-HT2 and tryptamine binding sites in rat brain. Gen Pharmacol. 1990. 21 (5) :759-62. |[3]Haenisch B, et al. Inhibitory potencies of trimipramine and its main metabolites at human monoamine and organic cation transporters. Psychopharmacology (Berl) . 2011 Sep. 217 (2) :289-95.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  5-HT1 Receptor; mLAG-3; α-1 microglobulin

• CAS Number :

  [739-71-9]