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Diazoxide-d3

CAT: 0804-HY-B1140SSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1140SSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Diazoxide-d3 is deuterium labeled Diazoxide. Diazoxide (Sch-6783) is an ATP-sensitive potassium channel activator, has the potential for hyperinsulinism treatment.
CAS Number
1432063-51-8
Product Name Alternative
Sch-6783-d3; SRG-95213-d3
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Autophagy; Isotope-Labeled Compounds; Potassium Channel
Type
Isotope-Labeled Compounds
Related Pathways
Autophagy; Membrane Transporter/Ion Channel; Others
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Solubility
10 mM in DMSO
Smiles
O=S1(C2=CC(Cl)=CC=C2NC(C([2H])([2H])[2H])=N1)=O
Molecular Formula
C8H4D3ClN2O2S
Molecular Weight
233.69
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Chowdhury UR, et al. ATP-sensitive potassium (K (ATP) ) channel openers diazoxide and nicorandil lower intraocular pressure in vivo. Invest Ophthalmol Vis Sci. 2013 Jul 22;54 (7) :4892-9.|[3]Coetzee WA, et al. Multiplicity of effectors of the cardioprotective agent, diazoxide. Pharmacol Ther. 2013 Nov;140 (2) :167-75.|[4]Virgili N, et al. K (ATP) channel opener diazoxide prevents neurodegeneration: a new mechanism of action viaantioxidative pathway activation. PLoS One. 2013 Sep 11;8 (9) :e75189.|[5]Wu H, et al. Diazoxide Attenuates Postresuscitation Brain Injury in a Rat Model of Asphyxial Cardiac Arrest by Opening Mitochondrial ATP-Sensitive Potassium Channels. Biomed Res Int. 2016;2016:1253842.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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