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Benfluorex

CAT: 0804-HY-B1058ASize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-B1058ASize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Benfluorex (JP-992) is a hepatic nuclear factor 4 alpha (HNF4α) activator.
CAS Number
[23602-78-0]
Product Name Alternative
JP-992
UNSPSC
12352005
Target
Orphan Nuclear Receptor; Orphan Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Benfluorex.html
Solubility
10 mM in DMSO
Smiles
FC(C1=CC(CC(NCCOC(C2=CC=CC=C2)=O)C)=CC=C1)(F)F
Molecular Formula
C19H20F3NO2
Molecular Weight
351.36
References & Citations
[1]Lee SH, et al. Identification of alverine and benfluorex as HNF4α activators. ACS Chem Biol. 2013 Aug 16;8 (8) :1730-6.|[2]Kohl C, et al. Effects of benfluorex on fatty acid and glucose metabolism in isolated rat hepatocytes: from metabolic fluxes to gene expression. Diabetes. 2002 Aug;51 (8) :2363-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
Biochem Pharmacol. 2022 Sep:203:115198.|EBioMedicine. 2022 Aug:82:104181.|Research Square Print. December 19th, 2022.|Adv Sci (Weinh) . 2024 Jul 5:e2403451.|Virol J. 2021 Sep 28;18 (1) :196.

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