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Fosinopril

CAT: 0804-HY-B0690Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-B0690Size:1 Each
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Description
Fosinopril (SQ28555 free acid) is the ester proagent of angiotensin-converting enzyme (ACE) inhibitor with an IC50 value of 0.18 μM. Fosinopril demonstrates a non-competitive inhibition effect on ACE activity with an Ki value of 1.675 μM[1][2].
CAS Number
98048-97-6
Product Name Alternative
SQ28555 (free acid)
UNSPSC
12352005
Target
Angiotensin-converting Enzyme (ACE) ; Apoptosis
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Neuroscience-Neurodegeneration
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/fosinopril.html
Solubility
10 mM in DMSO
Smiles
O=C(O)[C@H]1N(C(C[P@@](CCCCC2=CC=CC=C2)(O[C@H](OC(CC)=O)C(C)C)=O)=O)C[C@H](C3CCCCC3)C1
Molecular Formula
C30H46NO7P
Molecular Weight
563.66
References & Citations
[1]Ondetti, M.A., Structural relationships of angiotensin converting-enzyme inhibitors to pharmacologic activity. Circulation, 1988. 77 (6 Pt 2) : p. I74-8.|[2]Piepho, R.W., Overview of the angiotensin-converting-enzyme inhibitors. Am J Health Syst Pharm, 2000. 57 Suppl 1: p. S3-7.|[3]Sharma, S., et al., The hemodynamic effects of long-term ACE inhibition with fosinopril in patients with heart failure. Fosinopril Hemodynamics Study Group. Am J Ther, 1999. 6 (4) : p. 181-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched

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