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Levobupivacaine

CAT: 0804-HY-B0653Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-B0653Size:1 Each
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Description
Levobupivacaine ((S) - (-) -Bupivacaine) is a long-acting amide local agent that can suppress or relieve pain. Levobupivacaine exerts agent that can suppress or relieve pain. and analgesic effects through reversible blockade of neuronal sodium channel. Levobupivacaine can inhibit impulse transmission and conduction in cardiovascular and other tissues, possessing certain cardiac and CNS toxicity. Levobupivacaine is metabolized by hepatic cytochrome P450 (CYP450) enzymes in vivo. Levobupivacaine can also induce ferroptosis by miR-489-3p/SLC7A11 signaling in gastric cancer[1][2][3].
CAS Number
27262-47-1
Product Name Alternative
(S) - (-) -Bupivacaine
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Ferroptosis; Sodium Channel
Type
Reference compound
Related Pathways
Apoptosis; Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/levobupivacaine.html
Solubility
10 mM in DMSO
Smiles
O=C([C@H]1N(CCCC)CCCC1)NC2=C(C)C=CC=C2C
Molecular Formula
C18H28N2O
Molecular Weight
288.43
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Sanford M, et al. Levobupivacaine: a review of its use in regional anaesthesia and pain management. Drugs. 2010 Apr 16;70 (6) :761-91.|[2]Mao SH, et al. Levobupivacaine Induces Ferroptosis by miR-489-3p/SLC7A11 Signaling in Gastric Cancer. Front Pharmacol. 2021 Jun 9;12:681338.|[3]Marganella C, et al. Comparative effects of levobupivacaine and racemic bupivacaine on excitotoxic neuronal death in culture and N-methyl-D-aspartate-induced seizures in mice. Eur J Pharmacol. 2005 Aug 22;518 (2-3) :111-5.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched

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