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Latanoprost-d4

CAT: 0804-HY-B0577SSize: 500 μg (2.29 mM x 500 μL in Methyl Acetate)Dry Ice: NoHazardous: No
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CAT#:0804-HY-B0577SSize:500 μg (2.29 mM x 500 μL in Methyl Acetate)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Latanoprost-d4 is the deuterium labeled Latanoprost. Latanoprost (PHXA41) is a prostaglandin F2α analogue and an agonist for the FP prostanoid receptor, and lowers intraocular-pressure (IOP) .
Product Name Alternative
PHXA41-d4
UNSPSC
12352005
Target
Isotope-Labeled Compounds; Prostaglandin Receptor
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Others
Field of Research
Others
Concentration
2.29 mM * 500 μL in Methyl acetate
Purity
98.0
Solubility
10 mM in DMSO
Smiles
O[C@H](CC[C@H]1[C@@H](C[C@@H]([C@@H]1C/C=C\C([2H])(C([2H])(CC(OC(C)C)=O)[2H])[2H])O)O)CCC2=CC=CC=C2
Molecular Formula
C26H36D4O5
Molecular Weight
436.62
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Zheng J, et al. Latanoprost promotes neurite outgrowth in differentiated RGC-5 cells via the PI3K-Akt-mTOR signaling pathway. Cell Mol Neurobiol. 2011 May;31 (4) :597-604.|[3]Ooi YH, et al. Effect of bimatoprost, latanoprost, and unoprostone on matrix metalloproteinases and their inhibitors in human ciliary body smooth muscle cells. Invest Ophthalmol Vis Sci. 2009 Nov;50 (11) :5259-65.|[4]B'Ann True Gabelt, et al. Prostaglandin Subtype-Selective and Non-Selective IOP-Lowering Comparison in Monkeys.|[5]Pauly A, et al. In vitro and in vivo comparative toxicological study of a new preservative-free latanoprost formulation. Invest Ophthalmol Vis Sci. 2012 Dec 13;53 (13) :8172-80.|[6]Tsai S, et al. The effect of topical latanoprost on anterior segment anatomic relationships in normal dogs. Vet Ophthalmol. 2013 Sep;16 (5) :370-6.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
FP

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