Latanoprost-d4

• UNSPSC Description:

  Latanoprost-d4 is the deuterium labeled Latanoprost. Latanoprost (PHXA41) is a prostaglandin F2α analogue and an agonist for the FP prostanoid receptor, and lowers intraocular-pressure (IOP).

• Target Antigen:

  Isotope-Labeled Compounds; Prostaglandin Receptor

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  GPCR/G Protein;Others

• Field of Research:

  Others

• Purity:

  98.0

• Solubility:

  10 mM in DMSO

• Smiles:

  O[C@H](CC[C@H]1[C@@H](C[C@@H]([C@@H]1C/C=C\C([2H])(C([2H])(CC(OC(C)C)=O)[2H])[2H])O)O)CCC2=CC=CC=C2

• Molecular Weight:

  436.62

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Zheng J, et al. Latanoprost promotes neurite outgrowth in differentiated RGC-5 cells via the PI3K-Akt-mTOR signaling pathway. Cell Mol Neurobiol. 2011 May;31(4):597-604.|[3]Ooi YH, et al. Effect of bimatoprost, latanoprost, and unoprostone on matrix metalloproteinases and their inhibitors in human ciliary body smooth muscle cells. Invest Ophthalmol Vis Sci. 2009 Nov;50(11):5259-65.|[4]B'Ann True Gabelt, et al. Prostaglandin Subtype-Selective and Non-Selective IOP-Lowering Comparison in Monkeys.|[5]Pauly A, et al. In vitro and in vivo comparative toxicological study of a new preservative-free latanoprost formulation. Invest Ophthalmol Vis Sci. 2012 Dec 13;53(13):8172-80.|[6]Tsai S, et al. The effect of topical latanoprost on anterior segment anatomic relationships in normal dogs. Vet Ophthalmol. 2013 Sep;16(5):370-6.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Solution, -20°C, 2 years

• Clinical Information:

  No Development Reported