Nafcillin

• Description :

  Nafcillin, an antibiotic, is a reversible inhibitor of β-lactamase. Nafcillin exhibits bactericidal activity, and can be used for the research of staphylococcal infections[1][2][3][4].

• CAS Number :

  [147-52-4]

• UNSPSC :

  12352005

• Hazard Statement :

  H302-H312-H332

• Target :

  Antibiotic; Bacterial; Beta-lactamase

• Type :

  Reference compound

• Related Pathways :

  Anti-infection

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/nafcillin.html

• Solubility :

  10 mM in DMSO

• Smiles :

  OC([C@@H]1N(C2=O)[C@]([C@@H]2NC(C(C3=CC=CC=C3C=C4)=C4OCC)=O)([H])SC1(C)C)=O

• Molecular Formula :

  C21H22N2O5S

• Molecular Weight :

  414.47

• Precautions :

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

• References & Citations :

  [1]Tan, A.K., et al. Identification of the site of covalent attachment of nafcillin, a reversible suicide inhibitor of beta-lactamase. Biochem J, 1992. 281 (Pt 1) : p. 191-6.|[2]Palmer, D.L., et al. Bacterial wound colonization after broad-spectrum versus narrow-spectrum antibiotics. Ann Thorac Surg, 1995. 59 (3) : p. 626-31.|[3]Lawrence I. Mortin, et al. Rapid Bactericidal Activity of Daptomycin against Methicillin-Resistant and Methicillin-Susceptible Staphylococcus aureus Peritonitis in Mice as Measured with Bioluminescent Bacteria. Antimicrob Agents Chemother. 2007 May; 51 (5) : 1787-1794.|[4]Sakoulas G, et al. Nafcillin enhances innate immune-mediated killing of methicillin-resistant Staphylococcus aureus. J Mol Med (Berl) . 2014 Feb;92 (2) :139-49.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  β-lactam