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Flumequine-13C3

CAT: 0804-HY-B0526SSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0526SSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Flumequine-13C3 is the 13C3 labeled Flumequine. Flumequine (R-802) is a quinolone antibiotic, and acts as a topoisomerase II inhibitor, with an IC50 of 15 μM (3.92 μg/mL) .
CAS Number
1185049-09-5
UNSPSC
12352005
Target
Antibiotic; Bacterial; Isotope-Labeled Compounds; Topoisomerase
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Others
Applications
COVID-19-anti-virus
Field of Research
Infection; Cancer
Assay Protocol
https://www.medchemexpress.com/flumequine-13c3.html
Solubility
10 mM in DMSO
Smiles
O=[13C]1C2=CC(F)=CC3=C2N(C(CC3)C)C=[13C]1[13C](O)=O
Molecular Formula
C11 13C3H12FNO3
Molecular Weight
264.23
References & Citations
[1]Aller-Morán LM, et al. Evaluation of the in vitro activity of flumequine against field isolates of Brachyspira hyodysenteriae. Res Vet Sci. 2015 Dec;103:51-3.|[2]Giraud E, et al. Mechanisms of quinolone resistance and clonal relationship among Aeromonas salmonicida strains isolated from reared fish with furunculosis. J Med Microbiol. 2004 Sep;53 (Pt 9) :895-901.|[3]Kashida Y, et al. Mechanistic study on flumequine hepatocarcinogenicity focusing on DNA damage in mice. Toxicol Sci. 2002 Oct;69 (2) :317-21.|[4]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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