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Cloxacillin

CAT: 0804-HY-B0466ASize: 1 EachDry Ice: NoHazardous: No
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Description
Cloxacillin is an orally active antibacterial agent and β-lactamase inhibitor with an IC50 of 0.04 μM. Cloxacillin can suppress the S. aureus-induced inflammatory response by inhibiting the activation of MAPKs, NF-кB and NLRP3-related proteins[1][2][3].
CAS Number
61-72-3
UNSPSC
12352005
Hazard Statement
H302-H312-H332
Target
Antibiotic; Bacterial; Beta-lactamase
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cloxacillin.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(C)ON=C1C2=C(C=CC=C2)Cl)N[C@H]3[C@]4([H])N([C@@H](C(O)=O)C(C)(C)S4)C3=O
Molecular Formula
C19H18ClN3O5S
Molecular Weight
435.88
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501
References & Citations
[1]Zhou H, et al. The combination of cloxacillin, thioridazine and tetracycline protects mice against Staphylococcus aureus peritonitis by inhibiting α-Hemolysin-induced MAPK/NF-κB/NLRP3 activation. Int J Biol Macromol. 2022 Feb 15;198:1-10.|[2]Bergmann B, et al. Antibiotics with Interleukin-15 Inhibition Reduce Joint Inflammation and Bone Erosions but Not Cartilage Destruction in Staphylococcus aureus-Induced Arthritis. Infect Immun. 2018 Apr 23;86 (5) :e00960-17.|[3]Lupiola-Gómez PA, et al. Group 1 beta-lactamases of Aeromonas caviae and their resistance to beta-lactam antibiotics. Can J Microbiol. 2003 Mar;49 (3) :207-15.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Tetracycline

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ABDCOX5BCloxacillin
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444921-01Cloxacillin Benzathine

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