Vardenafil-d5

CAT: 0804-HY-B0442SSize: 500 µgDry Ice: NoHazardous: No
CAT#:0804-HY-B0442SSize:500 µg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Vardenafil-d5 is deuterium labeled Vardenafil. Vardenafil is a selective, orally active, potent inhibitor of phosphodiesterase-5 (PDE5), with an IC50 of 0.7 nM. Vardenafil shows selectivity over PDE1 (180 nM), PDE6 (11 nM), PDE2, PDE3, and PDE4 (>1000 nM) . Vardenafil competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. Vardenafil can be used for the research of erectile dysfunction[1][2].
CAS Number
[1189685-70-8]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Endogenous Metabolite; Isotope-Labeled Compounds; Phosphodiesterase (PDE)
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Solubility
10 mM in DMSO
Smiles
CC1=C2N(NC(C3=CC(S(=O)(N4CCN(CC4)C([2H])(C([2H])([2H])[2H])[2H])=O)=CC=C3OCC)=NC2=O)C(CCC)=N1
Molecular Formula
C23H27D5N6O4S
Molecular Weight
493.63
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Ashour AE, et al. Vardenafil dihydrochloride. Profiles Drug Subst Excip Relat Methodol. 2014;39:515-544.|[3]Saenz de Tejada I, et al. The phosphodiesterase inhibitory selectivity and the in vitro and in vivo potency of the new PDE5 inhibitor vardenafil. Int J Impot Res. 2001;13 (5) :282-290.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

Related Products

CatalogName
HY-B0442-01Vardenafil
HY-B0442S1Vardenafil-d4
HY-B0442R-01Vardenafil (Standard)
HY-B0442CVardenafil (dihydrochloride)
HY-137300Hydroxy vardenafil
HY-B0442A-01Vardenafil (hydrochloride)
HY-B0442CRVardenafil (dihydrochloride) (Standard)
HY-133724-01Vardenafil N-oxide
HY-129903-01N-Desethyl vardenafil
HY-B0442B-01Vardenafil (hydrochloride trihydrate)

Alternative Products

CatalogName
RG-A261143-01Vardenafil-D5
4396377-Despropyl 7-Methyl Vardenafil-d5
BUP15102-01Vardenafil
RM-V041413-01Hydroxy Vardenafil
RM-V041433-01Vardenafil-D7
MBS5811788Vardenafil oxopiperazine
sc-478708Norneo Vardenafil
sc-212602Pseudo Vardenafil
A10965-100Vardenafil 100mg
C03397-01Vardenafil dihydrochloride

Popular Products