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Nateglinide (Standard)

CAT: 0804-HY-B0422R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0422R-01Size:5 mg
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Description
Nateglinide (Standard) is the analytical standard of Nateglinide. This product is intended for research and analytical applications. Nateglinide, a D-phenylalanine derivative, is an orally active and short-acting insulinotropic agent and a DPP IV inhibitor. Nateglinide inhibits ATP-sensitive K+ channels in pancreatic β-cells. Nateglinide is used for the treatment of type 2 (non-insulin-dependent) diabetes mellitus[1][2].
CAS Number
105816-04-4
Product Name Alternative
A4166 (Standard) ; Senaglinide (Standard)
UNSPSC
12352005
Target
Dipeptidyl Peptidase; Potassium Channel; Reference Standards
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Others
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/nateglinide-standard.html
Solubility
10 mM in DMSO
Smiles
O=C(O)[C@@H](CC1=CC=CC=C1)NC([C@H]2CC[C@H](C(C)C)CC2)=O
Molecular Formula
C19H27NO3
Molecular Weight
317.42
References & Citations
[1]Christopher J. Dunn, et al. Nateglinide. OFILE Drugs 2000 Sep: 60 (3) : 6.|[2]Shiling Hu, et al. Interaction of nateglinide with KATP channel in h-cells underlies its unique insulinotropic action. European Journal of Pharmacology. 442 (2002) 163-171.|[3]Jian Luo, et al. Evaluating insulin secretagogues in a humanized mouse model with functional human islets. Metabolism. 2013 Jan;62 (1) :90-9.|[4]Duffy NA, et al. Effects of antidiabetic drugs on dipeptidyl peptidase IV activity: nateglinide is an inhibitor of DPP IV and augments the antidiabetic activity of glucagon-like peptide-1. Eur J Pharmacol. 2007 Jul 30;568 (1-3) :278-86.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Clinical Information
Launched

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