Nimesulide-d5

• Description :

  Nimesulide-d5 is a deuterium labeled Nimesulide. Nimesulide is a selective COX-2 inhibitor, with IC50s of 70 nM-70 μM in a time-dependent manner, but it shows no effect on COX-1 (IC50 >100 μM) . Nimesulide has potent anti-inflammatory, analgesic and antipyretic properties[1][2].

• UNSPSC :

  12352005

• Hazard Statement :

  H301-H312-H330-H410

• Target :

  COX; Isotope-Labeled Compounds

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Immunology/Inflammation; Others

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Solubility :

  10 mM in DMSO

• Smiles :

  CS(=O)(NC1=CC=C([N+]([O-])=O)C=C1OC2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])=O

• Molecular Formula :

  C13H7D5N2O5S

• Molecular Weight :

  313.34

• Precautions :

  P264-P270-P330-P405-P501

• References & Citations :

  [1]Vago T, et al. Effect of nimesulide action time dependence on selectivity towards prostaglandin G/H synthase/cyclooxygenase activity. Arzneimittelforschung. 1995 Oct;45 (10) :1096-8.|[2]Werner MF, et al. Nimesulide-induced antipyresis in rats involves both cyclooxygenase-dependent and independent mechanisms. Eur J Pharmacol. 2006 Aug 14;543 (1-3) :181-9.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported

• Isoform :

  COX-2

• CAS Number :

  [1330180-22-7]