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Clemastine

CAT: 0804-HY-B0298Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-B0298Size:1 Each
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Description
Clemastine (HS-592) is a potent and orally active histamine receptor H1 antagonist. Clemastine is an antihistamine mainly used for relieving symptoms of allergic reactions primarily by competing with histamine to bind H1 receptors. Anti-inflammatory effects[1][2].
CAS Number
15686-51-8
Product Name Alternative
HS-592; Meclastine
UNSPSC
12352005
Target
Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/clemastine.html
Purity
98.4100
Solubility
10 mM in DMSO
Smiles
CN1[C@@H](CCO[C@](C2=CC=CC=C2)(C3=CC=C(Cl)C=C3)C)CCC1
Molecular Formula
C21H26ClNO
Molecular Weight
343.89
References & Citations
[1]Clemastine. In: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. Bethesda (MD) : National Institute of Diabetes and Digestive and Kidney Diseases; January 16, 2017.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
H1 Receptor
Citation 01
Methods Mol Biol. 2023:2683:103-111.|Neurosci Bull. 2025 Jul 17.|Biochem Biophys Res Commun. 2020 Feb 19;522 (4) :862-868.|Br J Pharmacol. 2025 Jun;182 (12) :2730-2753.|Cell Prolif. 2021 Jan;54 (1) :e12953.|Exp Neurol. 2024 Dec 3:115086.|Microbiol Spectr. 2022 Apr 27;10 (2) :e0054121.|Prog Neuropsychopharmacol Biol Psychiatry. 2024 Feb 8:129:110901.|Redox Biol. 2025 Sep 20:87:103875.|Viruses. 2021 Jun 28;13 (7) :1255.

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BUP13611-01Clemastine
T0147-01Clemastine fumarate

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