Nicotinamide-15N,13C3

Nicotinamide-15N,13C3

• CAS Number: 2117346-85-5
• UNSPSC Description: Nicotinamide-15N,13C3 is the 13C-labeled and 15N-labeled Nicotinamide. Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.
• Target Antigen: Endogenous Metabolite; Isotope-Labeled Compounds; Sirtuin
• Type: Isotope-Labeled Compounds
• Related Pathways: Cell Cycle/DNA Damage;Epigenetics;Metabolic Enzyme/Protease;Others
• Field of Research: Neurological Disease; Cancer
• Assay Protocol: https://www.medchemexpress.com/nicotinamide-15n-13c3.html
• Solubility: 10 mM in DMSO
• Smiles: N[13C](C1=[13CH][15N]=[13CH]C=C1)=O
• Molecular Weight: 126.10
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Bhansali SG, et al. Nicotinamide prevents apoptosis in human cortical neuronal cells. Toxicol Mech Methods. 2006;16(4):173-80.|[3]Peck B, et al. SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2. Mol Cancer Ther. 2010 Apr;9(4):844-55.|[4]Fushima T, et al. Nicotinamide ameliorates a preeclampsia-like condition in mice with reduced uterine perfusion pressure. Am J Physiol Renal Physiol. 2016 Dec 7:ajprenal.00501.2016|[5]Roslan J, et al. Quercetin ameliorates oxidative stress, inflammation and apoptosis in the heart of streptozotocin-nicotinamide-induced adult male diabetic rats. Biomed Pharmacother. 2016 Dec 24;86:570-582|[6]Suzuki E, et al. Protective effect of nicotinamide against poly(ADP-ribose) polymerase-1-mediated astrocyte death depends on its transporter-mediated uptake. Life Sci. 2010 Apr 24;86(17-18):676-82.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported