Niacin (hydrochloride)

• Description:

  Niacin (Vitamin B3; Nicotinic acid) hydrochloride is an orally active B3 vitamin that is an essential nutrient for humans. Niacin hydrochloride plays a key role in energy metabolism, cell signaling cascades regulating gene expression and apoptosis. Niacin hydrochloride is also used in the study of cardiovascular diseases[1][2].

• Product Name Alternative:

  Nicotinic acid (hydrochloride) ; Vitamin B3 (hydrochloride)

• UNSPSC:

  12352005

• Target:

  Apoptosis; Endogenous Metabolite

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Metabolic Enzyme/Protease

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Cancer; Metabolic Disease; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/niacin-hydrochloride.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=CC=CN=C1)O.Cl

• Molecular Formula:

  C6H6ClNO2

• Molecular Weight:

  159.57

• References & Citations:

  [1]Areeg M Almubarak, et al. Supplementation with Niacin during in vitro maturation improves the quality of porcine embryos. Theriogenology. 2021 Jul 15;169:36-46. doi: 10.1016/j.theriogenology.2021.04.005. Epub 2021 Apr 18.|[2]Nobuhiro Hirakawa, et al. Anti-invasive activity of niacin and trigonelline against cancer cells. Biosci Biotechnol Biochem. 2005 Mar;69 (3) :653-8.|[3]Kang Cheng, et al. Antagonism of the prostaglandin D2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans. Proc Natl Acad Sci U S A. 2006 Apr 25;103 (17) :6682-7.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Isoform:

  Human Endogenous Metabolite; Microbial Metabolite

• CAS Number:

  [636-79-3]