Niacin (hydrochloride)

Niacin (hydrochloride)

• CAS Number: 636-79-3
• UNSPSC Description: Niacin (Vitamin B3; Nicotinic acid) hydrochloride is an orally active B3 vitamin that is an essential nutrient for humans. Niacin hydrochloride plays a key role in energy metabolism, cell signaling cascades regulating gene expression and apoptosis. Niacin hydrochloride is also used in the study of cardiovascular diseases[1][2].
• Target Antigen: Apoptosis; Endogenous Metabolite
• Type: Reference compound
• Related Pathways: Apoptosis;Metabolic Enzyme/Protease
• Applications: Metabolism-sugar/lipid metabolism
• Field of Research: Cancer; Metabolic Disease; Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/niacin-hydrochloride.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C1=CC=CN=C1)O.Cl
• Molecular Weight: 159.57
• References & Citations: [1]Areeg M Almubarak, et al. Supplementation with Niacin during in vitro maturation improves the quality of porcine embryos. Theriogenology. 2021 Jul 15;169:36-46. doi: 10.1016/j.theriogenology.2021.04.005. Epub 2021 Apr 18.|[2]Nobuhiro Hirakawa, et al. Anti-invasive activity of niacin and trigonelline against cancer cells. Biosci Biotechnol Biochem. 2005 Mar;69(3):653-8.|[3]Kang Cheng, et al. Antagonism of the prostaglandin D2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans. Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6682-7.
• Shipping Conditions: Room temperature
• Clinical Information: Launched