Ertapenem

• Description:

  Ertapenem (MK-0826) is a broad spectrum and long acting β-lactam antibiotic. Ertapenem has a broad-spectrum anti-anaerobic activity against a variety of anaerobes with a mode MIC of 0.12 μg/mL. Ertapenem can be used for the research of severe infections caused by bacteria in the skin, lungs, stomach, pelvis, and urinary tract[1][2].

• Product Name Alternative:

  MK-0826

• UNSPSC:

  12352005

• Hazard Statement:

  H302-H312-H332

• Target:

  Antibiotic; Bacterial

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ertapenem.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C(N12)=C(S[C@@H]3CN[C@H](C(NC4=CC=CC(C(O)=O)=C4)=O)C3)[C@H](C)[C@]2([H])[C@@H]([C@H](O)C)C1=O)O

• Molecular Formula:

  C22H25N3O7S

• Molecular Weight:

  475.51

• Precautions:

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

• References & Citations:

  [1]Kenneth E Aldridge. Ertapenem (MK-0826), a new carbapenem: comparative in vitro activity against clinically significant anaerobes. Diagn Microbiol Infect Dis. 2002 Oct;44 (2) :181-6.|[2]C J Gill, et al. In vivo activity and pharmacokinetic evaluation of a novel long-acting carbapenem antibiotic, MK-826 (L-749,345) . Antimicrob Agents Chemother. 1998 Aug;42 (8) :1996-2001.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Isoform:

  β-lactam

• Citation 01:

  J Antimicrob Chemother. 2023 Sep 5;78 (9) :2242-2253.|Proc Natl Acad Sci U S A. 2024 Jan 16;121 (3) :e2314514121.|Proc Natl Acad Sci U S A. 2025 Dec 2;122 (48) :e2524436122.|Adv Ther (Weinh) . 2024 Jan 12.|Biomed Res Int. 2018 Jul 2:2018:3579832.|J Antimicrob Chemother. 2020 Jul 1;75 (7) :1850-1858.|J Antimicrob Chemother. 2025 Nov 5:dkaf408.|J Clin Microbiol. 2024 May 7:e0152023.|Molecules. 2025 Mar 9;30 (6) :1224.|Nat Commun. 2021 Jul 22;12 (1) :4461.|Nat Commun. 2022 Mar 2;13 (1) :1116.

• CAS Number:

  [153832-46-3]