Ertapenem

• UNSPSC Description:

  Ertapenem (MK-0826) is a broad spectrum and long acting β-lactam antibiotic. Ertapenem has a broad-spectrum anti-anaerobic activity against a variety of anaerobes with a mode MIC of 0.12 μg/mL. Ertapenem can be used for the research of severe infections caused by bacteria in the skin, lungs, stomach, pelvis, and urinary tract[1][2].

• Target Antigen:

  Antibiotic; Bacterial

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ertapenem.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C(N12)=C(S[C@@H]3CN[C@H](C(NC4=CC=CC(C(O)=O)=C4)=O)C3)[C@H](C)[C@]2([H])[C@@H]([C@H](O)C)C1=O)O

• Molecular Weight:

  475.51

• References & Citations:

  [1]Kenneth E Aldridge. Ertapenem (MK-0826), a new carbapenem: comparative in vitro activity against clinically significant anaerobes. Diagn Microbiol Infect Dis. 2002 Oct;44(2):181-6.|[2]C J Gill, et al. In vivo activity and pharmacokinetic evaluation of a novel long-acting carbapenem antibiotic, MK-826 (L-749,345). Antimicrob Agents Chemother. 1998 Aug;42(8):1996-2001.J Antimicrob Chemother. 2023 Jul 31;dkad229.|Proc Natl Acad Sci U S A. 2024 Jan 16;121(3):e2314514121.|Adv Ther (Weinh). 2024 Jan 12.|Biomed Res Int. 2018 Jul 2;2018:3579832. |J Antimicrob Chemother. 2020 Jul 1;75(7):1850-1858.|J Clin Microbiol. 2024 May 7:e0152023.|Nat Commun. 2021 Jul 22;12(1):4461.|Nat Commun. 2022 Mar 2;13(1):1116.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  Launched

• CAS Number:

  153832-46-3