4-Phenylbutyric acid-d5

• UNSPSC Description:

  4-Phenylbutyric acid-d5 is the deuterium labeled 4-Phenylbutyric acid[1]. 4-Phenylbutyric acid (4-PBA) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research[2][3][4].

• Target Antigen:

  HDAC; Virus Protease

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Anti-infection;Cell Cycle/DNA Damage;Epigenetics

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Cancer

• Solubility:

  10 mM in DMSO

• Smiles:

  [2H]C1=C(CCCC(O)=O)C([2H])=C([2H])C([2H])=C1[2H]

• Molecular Weight:

  169.23

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Chang TH, et al. Enhanced growth inhibition by combination differentiation therapy with ligands of peroxisome proliferator-activated receptor-gamma and inhibitors of histone deacetylase in adenocarcinoma of the lung. Clin Cancer Res. 2002 Apr;8(4):1206-12.|[3]Frouco G, et, al. Sodium phenylbutyrate abrogates African swine fever virus replication by disrupting the virus-induced hypoacetylation status of histone H3K9/K14. Virus Res. 2017 Oct 15;242:24-29.|[4]Park HJ, et al. 4-Phenylbutyric acid protects against lipopolysaccharide-induced bone loss by modulating autophagy in osteoclasts. Biochem Pharmacol. 2018 May;151:9-17.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  64138-52-9