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Diphenidol

CAT: 0804-HY-A0270Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-A0270Size:1 Each
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Description
Diphenidol is a non-selective muscarinic M1-M4 receptor antagonist, has anti-arrhythmic activity. Diphenidol is also a potent non-specific blocker of voltage-gated ion channels (Na+, K+, and Ca2+) in neuronal cells. Diphenidol can be used in the study of antivertigo and antinausea[1][2][3][4][5].
CAS Number
972-02-1
UNSPSC
12352005
Hazard Statement
H315-H319-H320
Target
MAChR; Sodium Channel
Type
Reference compound
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/diphenidol.html
Solubility
10 mM in DMSO
Smiles
OC(C1=CC=CC=C1)(C2=CC=CC=C2)CCCN3CCCCC3
Molecular Formula
C21H27NO
Molecular Weight
309.45
Precautions
P264-P280-P302+P352-P305+P351+P338-P362
References & Citations
[1]Leung YM, et al. Inhibition of voltage-gated K+ channels and Ca2+ channels by diphenidol. Pharmacol Rep. 2012;64 (3) :739-44.|[2]Leung YM, et al. Diphenidol inhibited sodium currents and produced spinal anesthesia. Neuropharmacology. 2010 Jun;58 (7) :1147-52.|[3]Leung YM, et al. Diphenidol inhibited sodium currents and produced spinal anesthesia. Neuropharmacology. 2010 Jun;58 (7) :1147-52.|[4]Chen YW, et al. Systemic diphenidol reduces neuropathic allodynia and TNF-alpha overexpression in rats after chronic constriction injury. Neurosci Lett. 2013 Sep 27;552:62-5.|[5]Takeda N, et al. Neuropharmacological mechanisms of emesis. I. Effects of antiemetic drugs on motion- and apomorphine-induced pica in rats. Methods Find Exp Clin Pharmacol. 1995 Nov;17 (9) :589-90.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
MAChR1; mAChR2; mAChR3; mAChR4

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