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Spirapril

CAT: 0804-HY-A0230Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-A0230Size:1 Each
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Description
Spirapril is a potent and cross the blood-brain barrier angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Spirapril competitively binds to ACE and prevents the conversion of angiotensin I to angiotensin II. Spirapril is an orally active proagent of Spiraprilat and can be used for the research of hypertension, congestive heart failure[1][2][3].
CAS Number
83647-97-6
Product Name Alternative
SCH 33844
UNSPSC
12352005
Hazard Statement
H302-H312-H332
Target
Angiotensin-converting Enzyme (ACE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/spirapril.html
Solubility
10 mM in DMSO
Smiles
CCOC([C@H](CCC1=CC=CC=C1)N[C@@H](C)C(N2CC3(SCCS3)C[C@H]2C(O)=O)=O)=O
Molecular Formula
C22H30N2O5S2
Molecular Weight
466.61
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501
References & Citations
[1]Noble S, Sorkin EM. Spirapril. A preliminary review of its pharmacology and therapeutic efficacy in the treatment of hypertension. Drugs. 1995 May;49 (5) :750-66.|[2]Maul B, et al. Alcohol consumption is controlled by angiotensin II. FASEB J. 2001 Jul;15 (9) :1640-2.|[3]Olivetti G, et al. Spirapril prevents left ventricular hypertrophy, decreases myocardial damage and promotes angiogenesis in spontaneously hypertensive rats. J Cardiovasc Pharmacol. 1993 Mar;21 (3) :362-70.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched

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