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Remikiren

CAT: 0804-HY-A0184Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-A0184Size:1 Each
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Description
Remikiren (Ro 42-5892) is an orally active and highly specific renin inhibitor. Remikiren specifically inhibits human reninand human plasma renin with IC50 values of 0.7 and 0.8 nM, respectively. Remikiren also reduces mean arterial blood pressure in sodium-depleted marmosets and squirrel monkeys. Remikiren can be used in study of hypertension[1].
CAS Number
126222-34-2
Product Name Alternative
Ro 42-5892; Ro 42-5892/001
UNSPSC
12352005
Target
Renin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/remikiren.html
Solubility
10 mM in DMSO
Smiles
CC(C)(C)S(C[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC2=CN=CN2)C(N[C@H]([C@@H](O)[C@H](C3CC3)O)CC4CCCCC4)=O)=O)(=O)=O
Molecular Formula
C33H50N4O6S
Molecular Weight
630.84
References & Citations
[1]Fischli W, et al. Ro 42-5892 is a potent orally active renin inhibitor in primates. Hypertension. 1991 Jul;18 (1) :22-31.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched

Alternative Products

CatalogName
GTR19192936-01Remikiren
TRC-R143552-25MGRemikiren-d4

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