Alclometasone

CAT: 0804-HY-A0150Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-A0150Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Alclometasone (7a-Chloro-16a-methyl prednisolone) is a glucocorticoid and inhibits the release of pro-inflammatory mediators from leukocytes. Alclometasone can be used to relieve corticosteroid-responsive dermatoses, including atopic dermatitis, eczema, psoriasis and allergic dermatitis[1].
CAS Number
[67452-97-5]
Product Name Alternative
7a-​Chloro-​16a-​methyl prednisolone
UNSPSC
12352211
Hazard Statement
H301-H311-H331-H341
Target
Glucocorticoid Receptor
Type
Reference compound
Related Pathways
Immunology/Inflammation; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/alclometasone.html
Solubility
10 mM in DMSO
Smiles
C[C@@]12[C@](C(CO)=O)(O)[C@H](C)C[C@@]1([H])[C@]3([H])[C@H](Cl)CC4=CC(C=C[C@]4(C)[C@@]3([H])[C@@H](O)C2)=O
Molecular Formula
C22H29ClO5
Molecular Weight
408.92
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P403+P233-P405-P501
References & Citations
[1]Alclometasone|[2]Nishibe Y, et al. Species and sex differences in the inhibitory action of the corticosteroid alclometasone dipropionate on the hepatic drug-metabolizing system.Jpn J Pharmacol. 1989 Aug;50 (4) :435-43.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched

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