Iloprost-d4

CAT: 0804-HY-A0096S-01Size: 250 µgDry Ice: NoHazardous: No
CAT#:0804-HY-A0096S-01Size:250 µg
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Description
Iloprost-d4 (Ciloprost-d4) is the deuterium labeled Iloprost. Iloprost (ZK 36374) is a synthetic analogue of prostacyclin PGI2[1][2].
CAS Number
[1035094-10-0]
UNSPSC
12352211
Target
Isotope-Labeled Compounds; Prostaglandin Receptor
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Solubility
10 mM in DMSO
Smiles
C(=C/[C@H](C(CC#CC)C)O)\[C@@H]1[C@@]2([C@@](C/C(=C\CC(C(C(O)=O)([2H])[2H])([2H])[2H])/C2)(C[C@H]1O)[H])[H]
Molecular Formula
C22H28D4O4
Molecular Weight
364.51
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Della Bella S, et al. Novel mode of action of iloprost: in vitro down-regulation of endothelial cell adhesion molecules. Prostaglandins Other Lipid Mediat. 2001 Jun;65 (2-3) :73-83.|[3]van der Giessen WJ, et al. The effect of the stable prostacyclin analogue ZK 36374 on experimental coronary thrombosis in the pig. Thromb Res. 1984 Oct 1;36 (1) :45-51.|[4]Addonizio VP Jr, et al. Prevention of heparin-induced thrombocytopenia during open heart surgery with iloprost (ZK36374) . Surgery. 1987 Nov;102 (5) :796-807.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
IP

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