Rufinamide (Standard)

• Description:

  Rufinamide (Standard) is the analytical standard of Rufinamide (HY-A0042) . This product is intended for research and analytical applications. Rufinamide (CGP 33101) is an orally active antiepileptic compound that inhibits Na+ current activation, inhibits neuronal hyperexcitability, and has anticonvulsant effects. Rufinamide is used in the study of Lennox-Gastaut syndrome[1][2][3][4].

• Product Name Alternative:

  CGP 33101 (Standard) ; E 2080 (Standard) ; RUF 331 (Standard)

• UNSPSC:

  12352005

• Hazard Statement:

  H336-H351-H361

• Target:

  Reference Standards; Sodium Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel; Others

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/rufinamide-standard.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=CN(CC2=C(F)C=CC=C2F)N=N1)N

• Molecular Formula:

  C10H8F2N4O

• Molecular Weight:

  238.19

• Precautions:

  P261-P271-P280-P304+P340-P403+P233-P405-P501

• References & Citations:

  [1]Suter MR, Kirschmann G, Laedermann CJ, Rufinamide attenuates mechanical allodynia in a model of neuropathic pain in the mouse and stabilizes voltage-gated sodium channel inactivated state. Anesthesiology. 2013 Jan;118 (1) :160-72.|[2]Chen JL, et.al. Inhibition of resurgent Na+ currents by rufinamide. Neuropharmacology. 2024 Apr 1;247:109835.|[3]White HS, et.al. The anticonvulsant profile of rufinamide (CGP 33101) in rodent seizure models. Epilepsia. 2008 Jul;49 (7) :1213-20.|[4]Suter MR, et.al. Rufinamide attenuates mechanical allodynia in a model of neuropathic pain in the mouse and stabilizes voltage-gated sodium channel inactivated state. Anesthesiology. 2013 Jan;118 (1) :160-72.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• Clinical Information:

  Launched

• CAS Number:

  [106308-44-5]