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Rufinamide (Standard)

CAT: 0804-HY-A0042R-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-A0042R-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Rufinamide (Standard) is the analytical standard of Rufinamide (HY-A0042) . This product is intended for research and analytical applications. Rufinamide (CGP 33101) is an orally active antiepileptic compound that inhibits Na+ current activation, inhibits neuronal hyperexcitability, and has anticonvulsant effects. Rufinamide is used in the study of Lennox-Gastaut syndrome[1][2][3][4].
CAS Number
[106308-44-5]
Product Name Alternative
CGP 33101 (Standard) ; E 2080 (Standard) ; RUF 331 (Standard)
UNSPSC
12352005
Hazard Statement
H336-H351-H361
Target
Reference Standards; Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Others
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/rufinamide-standard.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CN(CC2=C(F)C=CC=C2F)N=N1)N
Molecular Formula
C10H8F2N4O
Molecular Weight
238.19
Precautions
P261-P271-P280-P304+P340-P403+P233-P405-P501
References & Citations
[1]Suter MR, Kirschmann G, Laedermann CJ, Rufinamide attenuates mechanical allodynia in a model of neuropathic pain in the mouse and stabilizes voltage-gated sodium channel inactivated state. Anesthesiology. 2013 Jan;118 (1) :160-72.|[2]Chen JL, et.al. Inhibition of resurgent Na+ currents by rufinamide. Neuropharmacology. 2024 Apr 1;247:109835.|[3]White HS, et.al. The anticonvulsant profile of rufinamide (CGP 33101) in rodent seizure models. Epilepsia. 2008 Jul;49 (7) :1213-20.|[4]Suter MR, et.al. Rufinamide attenuates mechanical allodynia in a model of neuropathic pain in the mouse and stabilizes voltage-gated sodium channel inactivated state. Anesthesiology. 2013 Jan;118 (1) :160-72.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Clinical Information
Launched

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