Paliperidone-d4

• Description:

  Paliperidone-d4 is the deuterium labeled Paliperidone. Paliperidone (9-Hydroxyrisperidone), the major active metabolite of Risperidone, is a dopamine D2 antagonist and 5-HT2A antagonist. Paliperidone is also active as an antagonist at α1 and α2 adrenergic receptors and H1-histaminergic receptors. Paliperidone, a antipsychotic agent, shows efficacy against schizophrenia[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H301

• Target:

  5-HT Receptor; Adrenergic Receptor; Dopamine Receptor

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Field of Research:

  Neurological Disease

• Solubility:

  10 mM in DMSO

• Smiles:

  FC1=CC=C(C(C2CCN(CC2)C([2H])([2H])C([2H])([2H])C3=C(C)N=C(C(CCC4)O)N4C3=O)=NO5)C5=C1

• Molecular Formula:

  C23H23D4FN4O3

• Molecular Weight:

  430.51

• Precautions:

  H301

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Mauri MC, Paletta S, Maffini M, et al. Clinical pharmacology of atypical antipsychotics: an update. EXCLI J. 2014;13:1163-1191. Published 2014 Oct 13.|[3]Peng L, et al. Paliperidone protects prefrontal cortical neurons from damages caused by MK-801 via Akt1/GSK3β signaling pathway. Schizophr Res. 2013 Jun;147 (1) :14-23.|[4]Yang MC, et al. Neuroprotection of paliperidone on SH-SY5Y cells against β-amyloid peptide (25-35), N-methyl-4-phenylpyridinium ion, and hydrogen peroxide-induced cell death. Psychopharmacology (Berl) . 2011 Oct;217 (3) :397-410.|[5]Kalman S, et al. 9-hydroxy-risperidone (9OHRIS) prevents stress-induced β-actin overexpression in rat hippocampus. Neuropsychopharmacol Hung. 2010 Sep;12 (3) :425-31.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• Isoform:

  5-HT2 Receptor; D2 Receptor

• CAS Number:

  [1020719-55-4]