Succinic anhydride-13C2

Succinic anhydride-13C2

• CAS Number: 67519-25-9
• UNSPSC Description: Succinic anhydride-13C2 is the 13C labeled Succinic anhydride[1]. Succinic anhydride is a cyclic anhydride and a nonclaevable ADC linker extracted from patent WO2009064913A1. Succinic anhydride can react with compound 4 of the patent to link the proagent to an amine or hydroxy 1 group of a targeting polypeptide[2].
• Target Antigen: ADC Linker
• Type: Isotope-Labeled Compounds
• Related Pathways: Antibody-drug Conjugate/ADC Related
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/succinic-anhydride-13c2.html
• Solubility: 10 mM in DMSO
• Smiles: O=[13C]1O[13C](CC1)=O
• Molecular Weight: 102.06
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Dale Boger.et al. Chimer containing a targeting portion linked to a scission-activated duocarmycin-type prodrug. WO2009064913A1.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported