Palbociclib-d8

CAT: 0804-HY-50767SSize: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-50767SSize:1 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Palbociclib-d8 is a deuterium labeled Palbociclib. Palbociclib is a selective and orally active CDK4 and CDK6 inhibitor with IC50s of 11 and 16 nM, respectively. Palbociclib has the potential for ER-positive and HER2-negative breast cancer research[1].
CAS Number
[1628752-83-9]
Product Name Alternative
PD 0332991-d8
UNSPSC
12352005
Hazard Statement
H341, H361, H373, H411
Target
CDK; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Cell Cycle/DNA Damage; Others
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
99.84
Solubility
DMSO : 1mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 8.33 mg/mL (ultrasonic; warming; adjust pH to 3 with HCl; heat to 80°C)
Smiles
O=C1N(C2=NC(NC3=NC=C(C=C3)N4C([2H])(C([2H])(NC([2H])(C4([2H])[2H])[2H])[2H])[2H])=NC=C2C(C)=C1C(C)=O)C5CCCC5
Molecular Formula
C24H21D8N7O2
Molecular Weight
455.58
Precautions
H341, H361, H373, H411
References & Citations
[1]Fry DW, et al. Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts. Mol Cancer Ther. 2004 Nov;3 (11) :1427-38.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
CDK4; CDK6

Related Products

CatalogName
HY-50767-01Palbociclib
HY-50767BPalbociclib (dihydrochloride)
HY-50767DPalbociclib (orotate)
HY-50767C-01Palbociclib (hydrochloride)
HY-50767A-01Palbociclib (monohydrochloride)
HY-130296-01Palbociclib-propargyl
HY-168662Palbociclib-CH2COOH
HY-50767R-01Palbociclib (Standard)
HY-W654305Palbociclib-d4
HY-A0065-01Palbociclib (isethionate)

Alternative Products

CatalogName
MBS5767271Palbociclib-d8
RM-P020409-01Palbociclib-d8 (controlled substance)
TMIH-0387-01N-Formyl Palbociclib-d8
MBS3605080-01Palbociclib
446389-01Desoxo-palbociclib
T33865-01Palbociclib-SMCC

Popular Products