Apixaban-d3

• Description :

  Apixaban-d3 (BMS-562247-01-d3) is the deuterium labeled Apixaban (HY-50667) [1]. Apixaban (BMS-562247-01) is a highly selective, reversible and orally active inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively[2]. Apixaban is in development for the prevention and treatment of various thromboembolic diseases[3].

• Product Name Alternative :

  BMS-562247-01-d3

• UNSPSC :

  12352005

• Target :

  Factor Xa; Isotope-Labeled Compounds

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Metabolic Enzyme/Protease; Others

• Field of Research :

  Others

• Purity :

  99.9

• Solubility :

  DMF : ≥ 3mg/mL|DMSO : ≥ 5mg/mL

• Smiles :

  O=C1C2=C(CCN1C3=CC=C(N4C(CCCC4)=O)C=C3)C(C(N)=O)=NN2C5=CC=C(C=C5)OC([2H])([2H])[2H]

• Molecular Formula :

  C25H22D3N5O4

• Molecular Weight :

  462.52

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported

• CAS Number :

  [1131996-12-7]