Elocalcitol

• Description :

  Elocalcitol (BXL-628), a vitamin D analogue, is a selective, orally active vitamin D receptor (VDR) agonist. Elocalcitol shows anti-inflammatory activity. Elocalcitol inhibits growth of prostate cancer cells[1][2].

• CAS Number :

  [199798-84-0]

• Product Name Alternative :

  BXL-628; Ro-26-9228

• UNSPSC :

  12352211

• Target :

  Apoptosis; VD/VDR

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Vitamin D Related/Nuclear Receptor

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Endocrinology; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/elocalcitol.html

• Purity :

  99.2

• Solubility :

  DMSO : 30 mg/mL (ultrasonic; warming)

• Smiles :

  C[C@@]12[C@](CC=C2[C@@H](C)C/C=C/C(CC)(O)CC)([H])/C(CCC1)=C/C=C3C([C@H](C[C@@H](C\3)O)F)=C

• Molecular Formula :

  C29H43FO2

• Molecular Weight :

  442.65

• References & Citations :

  [1]Mariani M, et al. The selective vitamin D receptor agonist, elocalcitol, reduces endometriosis development in a mouse model by inhibiting peritoneal inflammation. Hum Reprod. 2012 Jul;27 (7) :2010-9. |[2]Marchiani S, et al. The vitamin D analogue BXL-628 inhibits growth factor-stimulated proliferation and invasion of DU145 prostate cancer cells. J Cancer Res Clin Oncol. 2006 Jun;132 (6) :408-16.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2