AIC-292

• Description :

  AIC-292 is a potent and selective inhibitor of HIV-1 nonnucleoside reverse transcriptase. AIC-292 inhibits wild-type HIV-1 laboratory strains at low nanomolar concentrations. AIC-292 displays potent antiviral in vivo efficacy in a mouse xenograft model. AIC-292 has the potential for the research of HIV-1 infection[1].

• UNSPSC :

  12352005

• Target :

  HIV

• Type :

  Reference compound

• Related Pathways :

  Anti-infection

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/aic-292.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C1NCN(C(C2=NN(C3=CC=C(F)C(Cl)=C3)C(C4=CC(F)=CC(Cl)=C4)=C2)=O)C1

• Molecular Formula :

  C19H12Cl2F2N4O2

• Molecular Weight :

  437.23

• References & Citations :

  [1]Wildum S, et al. In vitro and in vivo activities of AIC292, a novel HIV-1 nonnucleoside reverse transcriptase inhibitor. Antimicrob Agents Chemother. 2013;57 (11) :5320-5329.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• Isoform :

  HIV-1

• CAS Number :

  [1187917-12-9]