GSK1521498

• Description:

  GSK1521498 is a potent and selective μ-opioid receptor (MOR) antagonist. GSK1521498 has the potential for disorders of compulsive consumption of food, alcohol, and agents[1].

• UNSPSC:

  12352005

• Target:

  Opioid Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/gsk1521498.html

• Solubility:

  10 mM in DMSO

• Smiles:

  FC1=C (CNC2CC3=C (C=CC=C3) C2) C (F) =CC (C4=CC=CC (C5=NC=NN5) =C4) =C1.O=P (O) (O) O

• Molecular Formula:

  C24H23F2N4O4P

• Molecular Weight:

  500.43

• References & Citations:

  [1]Giuliano C, et al. The Novel μ-Opioid Receptor Antagonist GSK1521498 Decreases Both Alcohol Seeking and Drinking: Evidence from a New Preclinical Model of Alcohol Seeking. Neuropsychopharmacology. 2015 Dec;40 (13) :2981-92.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• Isoform:

  μ Opioid Receptor/MOR

• CAS Number:

  1426543-84-1