GSK1521498

• Description :

  GSK1521498 is a potent and selective μ-opioid receptor (MOR) antagonist. GSK1521498 has the potential for disorders of compulsive consumption of food, alcohol, and agents[1].

• UNSPSC :

  12352005

• Target :

  Opioid Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/gsk1521498.html

• Solubility :

  10 mM in DMSO

• Smiles :

  FC1=C(CNC2CC3=C(C=CC=C3)C2)C(F)=CC(C4=CC=CC(C5=NC=NN5)=C4)=C1.O=P(O)(O)O

• Molecular Formula :

  C24H23F2N4O4P

• Molecular Weight :

  500.43

• References & Citations :

  [1]Giuliano C, et al. The Novel μ-Opioid Receptor Antagonist GSK1521498 Decreases Both Alcohol Seeking and Drinking: Evidence from a New Preclinical Model of Alcohol Seeking. Neuropsychopharmacology. 2015 Dec;40 (13) :2981-92.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• Isoform :

  μ Opioid Receptor/MOR

• CAS Number :

  [1426543-84-1]