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RFI-641

CAT: 0804-HY-19874Size: 1 EachDry Ice: NoHazardous: No
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Description
RFI-641 is a selective inhibitor of the respiratory syncytial virus (RSV), with an IC50 of 50 nM. RFI-641 inhibit binding and fusion of enveloped virus via interaction with the viral fusion protein[1].
CAS Number
197366-24-8
UNSPSC
12352005
Target
RSV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/rfi-641.html
Solubility
10 mM in DMSO
Smiles
O=C(CN(S(=O)(C1=CC(NC2=NC(NC3=CC(S(=O)(O[Na])=O)=C(C4=CC=C(NC5=NC(NC6=CC=CC(S(=O)(N(CC(N)=O)CC(N)=O)=O)=C6)=NC(NC7=CC=CC(S(=O)(N(CC(N)=O)CC(N)=O)=O)=C7)=N5)C=C4S(=O)(O[Na])=O)C=C3)=NC(NC8=CC=CC(S(=O)(N(CC(N)=O)CC(N)=O)=O)=C8)=N2)=CC=C1)=O)CC(N)=O)N
Molecular Formula
C58H60N24Na2O22S6
Molecular Weight
1683.61
References & Citations
[1]Nikitenko AA, et, al. The discovery of RFI-641 as a potent and selective inhibitor of the respiratory syncytial virus. Bioorg Med Chem Lett. 2001 Apr 23;11 (8) :1041-4.|[2]Razinkov V, et, al. RFI-641 inhibits entry of respiratory syncytial virus via interactions with fusion protein. Chem Biol. 2001 Jul;8 (7) :645-59.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

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