Sandramycin

CAT: 0804-HY-19829Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-19829Size:1 mg
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Description
Sandramycin ia a cyclic depsipeptide antibiotic isolated from cultured broth of a Nocardioides sp. Sandramycin is also a DNA intercalator that potently binds DNA and is an ADC cytotoxin. Sandramycin is active against Gram-positive bacteria and has potent antitumor activity[1][2][3].
CAS Number
[100940-65-6]
UNSPSC
12352005
Target
ADC Payload; Antibiotic; Bacterial
Type
Natural Products
Related Pathways
Antibody-drug Conjugate/ADC Related; Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/sandramycin.html
Solubility
10 mM in DMSO
Smiles
CC(C)[C@@H](C(OC[C@@H](NC(C1=C(O)C=C(C=CC=C2)C2=N1)=O)C3=O)=O)N(C)C(CN(C)C(CNC([C@@H]4CCCCN4C([C@@H](COC([C@H](C(C)C)N(C)C(CN(C)C(CNC([C@H]5N3CCCC5)=O)=O)=O)=O)NC(C6=C(O)C=C(C=CC=C7)C7=N6)=O)=O)=O)=O)=O
Molecular Formula
C60H76N12O16
Molecular Weight
1221.32
References & Citations
[1]J A Matson, et al. Sandramycin, a Novel Antitumor Antibiotic Produced by a Nocardioides Sp. Production, Isolation, Characterization and Biological Properties. J Antibiot (Tokyo) . 1989 Dec;42 (12) :1763-7.|[2]Katsushi Katayama, et al. Total Synthesis of Sandramycin and Its Analogues via a Multicomponent Assemblage. Org Lett. 2014 Jan 17;16 (2) :428-31.|[3]D L Boger, et al. DNA Binding Properties of Key Sandramycin Analogues: Systematic Examination of the Intercalation Chromophore. Bioorg Med Chem. 1999 Feb;7 (2) :315-21.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Traditional Cytotoxic Agents

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