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I-BET282E

CAT: 0804-HY-19760BSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-19760BSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
I-BET282E is a pan-inhibitor of all eight BET bromodomains, and selectivity over other representative bromodomain-containing proteins. I-BET282E shows pIC50s ranging 6.4-7.7 for BRD2 (BD1/BD2), BRD2 (BD1/BD), BRD3 (BD1/BD), and BRD4 (BD1/BD) [1].
CAS Number
2885162-99-0
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/i-bet282e.html
Solubility
10 mM in DMSO
Smiles
CS(=O)(O)=O.COC1=C(C=C(C2=C1)N=CC3=C2N([C@H](C)COC)C(C4CCOCC4)=N3)C5=C(ON=C5C)C
Molecular Formula
C26H34N4O7S
Molecular Weight
546.64
References & Citations
[1]Jones KL, et al. Discovery of a Novel Bromodomain and Extra Terminal Domain (BET) Protein Inhibitor, I-BET282E, Suitable for Clinical Progression. J Med Chem. 2021;64 (16) :12200-12227.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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