Vorozole

• Description:

  Vorozole is a potent and selective, orally active non-steroidal aromatase inhibitor[1][2]. Vorozole shows antitumor activity in vivo. Vorozole has the potential for the research of mammary cancer[3].

• Product Name Alternative:

  (+) -Vorozole; R83842

• UNSPSC:

  12352005

• Target:

  Cytochrome P450

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/vorozole.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CN1N=NC2=CC=C([C@H](C3=CC=C(Cl)C=C3)N4N=CN=C4)C=C21

• Molecular Formula:

  C16H13ClN6

• Molecular Weight:

  324.77

• References & Citations:

  [1]Wouters W, et al. Pharmacology of vorozole. J Steroid Biochem Mol Biol. 1993 Mar;44 (4-6) :617-21.|[2]Wiseman LR, et al. Vorozole. Drugs Aging. 1997 Sep;11 (3) :245-50; discussion 251-2.|[3]Lubet RA, et al. Chemopreventive effects of the aromatase inhibitor vorozole (R 83842) in the methylnitrosourea-induced mammary cancer model. Carcinogenesis. 1998 Aug;19 (8) :1345-51.|[4]Wouters W, et al. Pharmacology of vorozole. J Steroid Biochem Mol Biol. 1993 Mar;44 (4-6) :617-21.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• Isoform:

  Aromatase/CYP19A1

• CAS Number:

  [129731-10-8]