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DU125530

CAT: 0804-HY-19283Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-19283Size:1 Each
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Description
DU125530 is a potent and selective5-HT1A receptor antagonist with Ki values of 0.7, 890, 1200, 240, 750, 1100 nM for 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2C, 5-HT3, respectively. DU125530 shows antidepressant effects[1][2].
CAS Number
161611-99-0
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/du125530.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C2C=CC=C1)N(CCCCN3CCN(C4=C5OCCOC5=CC(Cl)=C4)CC3)S2(=O)=O
Molecular Formula
C23H26ClN3O5S
Molecular Weight
491.99
References & Citations
[1]Mos J, et al. The putative 5-HT1A receptor antagonist DU125530 blocks the discriminative stimulus of the 5-HT1A receptor agonist flesinoxan in pigeons. Eur J Pharmacol. 1997 May 1;325 (2-3) :145-53.|[2]Scorza MC, et al. Preclinical and clinical characterization of the selective 5-HT (1A) receptor antagonist DU-125530 for antidepressant treatment. Br J Pharmacol. 2012 Nov;167 (5) :1021-34.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
5-HT1 Receptor;5-HT2 Receptor; lactoferrin; mLAG-3; α-1 microglobulin

Alternative Products

CatalogName
LGA61199-01DU125530

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