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1400W

CAT: 0804-HY-18730-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-18730-01Size:5 mg
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Description
1400W is a slow, tight binding, and highly selective inducible nitric-oxide synthase (iNOS) inhibitor, with a Kd value ≤ 7 nM. 1400W inhibits iNOS induction in microglial cells, and reduces generation of NO, thereby mitigating oxidative stress and neuronal cell apoptosis in the rat cerebral cortex, and improving the spatial memory dysfunction caused by acute hypobaric hypoxia-reoxygenation[1][2].
CAS Number
[180001-34-7]
Product Name Alternative
W1400
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Apoptosis; NO Synthase
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/1400w.html
Purity
98.49
Solubility
10 mM in DMSO
Smiles
CC(NCC1=CC=CC(CN)=C1)=N
Molecular Formula
C10H15N3
Molecular Weight
177.25
Precautions
H315, H319, H320
References & Citations
[1]Garvey EP, et al. 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo. J Biol Chem. 1997 Feb 21;272 (8) :4959-63.|[2]Shi Q, et al. 1400W ameliorates acute hypobaric hypoxia/reoxygenation-induced cognitive deficits by suppressing the induction of inducible nitric oxide synthase in rat cerebral cortex microglia. Behav Brain Res. 2017 Feb 15;319:188-199.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
BioRxiv. 2025 Feb 17.|ISME J. 2024 Jan 8;18 (1) :wrae014.|ACS Nano. 2025 Mar 11;19 (9) :9390-9411.|Aging Cell. 2025 Feb 6:e14502.|Biochem Biophys Res Commun. 2025 Jan 19:749:151345.|Biomed Pharmacother. 2022 Jul;151:113098.|Biomed Pharmacother. 2022 Sep;153:113532.|Cell Metab. 2025 Jan 7;37 (1) :291-304.e9.|Cell Rep. 2022 Feb 15;38 (7) :110391.|Int J Biol Sci. 2020 Mar 5;16 (9) :1563-1574.|Int J Ophthalmol. 2022 Jul 18;15 (7) :1053-1061.|iScience. 2023 Jul 10;26 (8) :107353.|J Physiol. 2024 Jul 26.|J Transl Med. 2023 Nov 25;21 (1) :852.|Microvasc Res. 2023 Mar:146:104468.|Mol Cell Biochem. 2025 Aug 3.|Mol Cell. 2020 Jan 2;77 (1) :95-107.e5.|Mucosal Immunol. 2024 Apr;17 (2) :288-302.|Neuropharmacology. 2025 Aug 29:280:110662.|Redox Biol. 2023 Nov:67:102905.|Sci Total Environ. 2020 Jan 1;698:134294.|Signal Transduct Target Ther. 2025 Jul 3;10 (1) :209.|Skelet Muscle. 2022 Jul 29;12 (1) :19.|University of Jena. 2023 Dec.

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