P2X7-IN-2

• Description :

  P2X7-IN-2 (compound 58) is a P2X7 receptor inhibitor. P2X7-IN-2 inhibits IL-Iβ release with an IC50 value of 0.01 nM. P2X7-IN-2 can be used for the research of autoimmunity, inflammation and cardiovascular disease[1].

• UNSPSC :

  12352005

• Target :

  Interleukin Related; P2X Receptor

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation; Membrane Transporter/Ion Channel

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/p2x7-in-2.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(NC1=C(C)C=CC2=C1C=CN([C@H](C)CN)C2=O)CC3=CC=C(C(F)(F)F)C(F)=C3

• Molecular Formula :

  C22H21F4N3O2

• Molecular Weight :

  435.41

• References & Citations :

  [1]Kelly, Michael G, et al. Preparation of isoquinolonecarboxamides as P2X7 purinoceptor modulators and uses thereof. WO2008112205 A1. 2008.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1058709-63-9]