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P2X7-IN-2

CAT: 0804-HY-18725Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-18725Size:1 Each
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Description
P2X7-IN-2 (compound 58) is a P2X7 receptor inhibitor. P2X7-IN-2 inhibits IL-Iβ release with an IC50 value of 0.01 nM. P2X7-IN-2 can be used for the research of autoimmunity, inflammation and cardiovascular disease[1].
CAS Number
1058709-63-9
UNSPSC
12352005
Target
Interleukin Related; P2X Receptor
Type
Reference compound
Related Pathways
Immunology/Inflammation; Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/p2x7-in-2.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=C(C)C=CC2=C1C=CN([C@H](C)CN)C2=O)CC3=CC=C(C(F)(F)F)C(F)=C3
Molecular Formula
C22H21F4N3O2
Molecular Weight
435.41
References & Citations
[1]Kelly, Michael G, et al. Preparation of isoquinolonecarboxamides as P2X7 purinoceptor modulators and uses thereof. WO2008112205 A1. 2008.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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