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HLI98C

CAT: 0804-HY-18327Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-18327Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HLI98C is a ubiquitin ligase inhibitor. HLI98C inhibits p53 ubiquitylation. HLI98C inhibits HDM2 auto-ubiquitylation[1].
CAS Number
317326-90-2
UNSPSC
12352005
Target
E1/E2/E3 Enzyme; MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hli98c.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC2=CC([N+]([O-])=O)=CC=C2N(C3=CC=CC(Cl)=C3)C1=N4)NC4=O
Molecular Formula
C17H9ClN4O4
Molecular Weight
368.73
References & Citations
[1]Yang Y, et al. Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells. Cancer Cell. 2005 Jun;7 (6) :547-59.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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MBS5777256HLI98C

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