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Takeda-6D

CAT: 0804-HY-18318Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-18318Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Takeda-6D (compound 6d) is an orally active and potent BRAF/VEGFR2 inhibitor, with IC50 values of 7.0 and 2.2 nM, respectively. Takeda-6D shows antiangiogenesis by suppressing the VEGFR2 pathway in 293/KDR and VEGF-stimulated HUVEC cells.Takeda-6D shows significant suppression of ERK1/2 phosphorylation. Takeda-6D shows antitumor activity[1].
CAS Number
1125632-93-0
UNSPSC
12352005
Target
PERK; Raf; VEGFR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/takeda-6d.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC(OC2=CC=C3C(SC(NC(C4CC4)=O)=N3)=N2)=CC=C1F)C5=CC=CC(C6(C#N)CC6)=C5Cl
Molecular Formula
C27H19ClFN5O3S
Molecular Weight
547.99
References & Citations
[1]Okaniwa M, et al. Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors. 1. Exploration of [5,6]-fused bicyclic scaffolds. J Med Chem. 2012 Apr 12;55 (7) :3452-78.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
B-Raf; VEGFR2/KDR/Flk-1

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